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Iodine Protocol
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    About the Iodine Supplementation Protocol
             --- Not Just For Breast Cancer Patients

    Physicians Guy Abraham, MD, David Brownstein, MD, and Jorge Flechas, MD,
    have treated more than 4,000 patients with iodine supplementation.  The
    protocol below is suggested by their writings and lectures. We acknowledge
    with appreciation their pioneering research and generous contributions to
    the field of Iodine Therapy.  See references below the protocol.

    Iodine and Companion Nutrients

    From October 2007 Iodine Conference

  • 50 mg Iodoral minimum for breast cancer (may start with 12.5 mg).
    Some practitioners may recommend another form of iodine such as
    Lugol's solution.  Iodoral is the Lugol's formula in tablet form especially
    designed to avoid gastric irritation.

  • Vitamin C - 3,000 mg per day (more may be necessary to detox bromide).

  • 300-600 mg magnesium oxide or comparable magnesium supplement.

  • 200 mcg selenium.

  • 500 mg niacin (B3) twice a day. (NOT niacinamide) Start lower to avoid
    flush. *See update in left margin on the ATP Cofactor as an alternative.

  • 100 mg Vitamin B2 three times a day. *See update in left margin on the
    ATP Cofactor as an alternative.

  • A comprehensive vitamin and nutrition program.

  • (Feb 2008) Dr. Guy Abraham cautions that "excess calcium
    supplementation (2,000-3,000 md/day) has been the most common
    cause of poor response to iodine supplementation." Vitamin Research
    News Vol. 22. Number 2.

24 Hour Iodine Loading Test Now Essential

    The Iodine specialists have recently discovered it is essential to have the 24
    Hour Iodine Loading Test before implementing iodine supplementation in
    order to investigate the presence of a possible iodine absorption defect. If a
    patient has a normal or high Loading Test score in the presence of known
    iodine deficiency condition such as breast or thyroid disease, a defect in the
    Sodium Iodide Symporter (NIS) mechanism is suspected. The iodine taken
    during the loading test may pass into the urine unabsorbed giving a false
    normal reading. Follow your physician's iodine dosing carefully to see how
    the iodine test result  changes.

  • The doctors find that the most common side effects are usually
    resolved with 3 grams of vitamin C and/or the salt loading protocol.

  • Be aware of iodine-related bromide detox symptoms. Symptoms of
    "bromism" may occur in some people. Click here for a list of recorded
    bromide symptoms. Patients are usually advised to cut back on iodine,
    *pulse-dose (see below) and salt-load more frequently.

    Important: The following protocol should be implemented only under your
    doctor's supervision and monitored with the appropriate laboratory work and
    thyroid studies. Report any side effects to your physician. Do not take iodine
    if you are allergic to iodized salt.

    Salt Loading Protocol for Possible Bromide Side Effects

    Orthoiodosupplementation induced and increased mobilization of bromine from
    storage sites, with increased urinary excretion of bromide. --Guy Abraham, MD

    Certain iodine-literate doctors feel the bromide excreted by iodine therapy
    can be eliminated more efficiently by the chloride present in mineral-rich
    unprocessed sea salt. The salt is added to water in a specific way. Eating
    salty food is not effective. Table salt is only used in an emergency.

    Many iodine takers found the Salt Loading Protocol devised by Dr. William
    Shevin (and presented at the February '07 Iodine Conference) to be
    effective in eliminating the side effects such as bromide sedation, acne,
    brain fog, brassy taste, mouth sores, frontal headache or other symptoms
    which occur in a small percentage of patients.

  • 1/4 teaspoon salt dissolved in 1/2 cup warm water.  Follow immediately
    with 12-16 oz pure water.

  • Repeat in 30-45 minutes if needed. May repeat again until copious
    urination begins.

  • Observe subjective response (usually within several hours).

  • Iodine Investigation Project participants have found 1/2 teaspoon salt
    dissolved in the recommended amount of water works faster than the
    1/4 teaspoon dosage.

    * Pulse dosing of iodine has often helped our participants with detox
    symptoms:  taking a two day break from iodine supplementation as needed
    seems to enhance the kidneys' ability to excrete bromide. These are only our
    observations as educated patients. Consult your own physician about your
    particular iodine regimen.

    No consensus exists on how important the salt loading may be to an iodine
    therapy strategy if the patient does not have adverse symptoms.

    Be sure to ask your doctor before implementing salt loading or any medical
    strategy.

    References:

    1.  Brownstein, Why You Need It, Why You Can't Live Without It, (Third Edition) Medical Alternative Press, West
    Bloomfield, MI 2006. See drbrownstein.com.

    2. Abraham, GE, The Historical Background of the Iodine Project, The Original Internist 2005

    3. Abraham, GE, Iodine Supplementation Markedly Increases Urinary Excretion of Fluoride and Bromide,
    Townsend Letter 2003

    4. Abraham, G.E., Brownstein, D., Evidence that the administration of Vitamin C improves a defective cellular
    transport mechanism for iodine: A case report. The Original Internist, 12(3):125-130, 2005
    [excerpt] Elevated bromide levels were observed in urine and serum samples, twenty times the levels
    reported in the literature in normal subjects(8,9). Mild bromism may have been the cause of the oxidative
    damage to the iodine transport system and the side effects to orthoiodosupplementation. Chloride competes
    with bromide at the renal level and increases the renal clearance of bromide (10,11). Sodium chloride at 10
    gm/day for one week resulted in marked increase in urine bromide levels, and a sharp drop in serum bromide.
    While on the chloride load, urinary frequency improves for the first time in 5 years, but fatigue worsened and
    she experienced facial and body acne. No significant change in symptomatology was observed while on
    Vitamin C. The responses of her symptoms to various treatments modalities by self-assessment are
    summarized in Table I. The treatment modalities are cumulative and added sequentially in the patient's
    management. Measurements of serum and urine bromide and iodide levels reported in this manuscript were
    performed by ion-selective electrode assay, following chromatography on strong anion exchanger cartridges,
    as previously described (3,7).

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    The statements above have not been evaluated by the U.S. Food & Drug Administration.  The supplements
    discussed are not intended to diagnose, treat, cure, or prevent any disease.  Do not take iodine without
    the supervision of an Iodine-Literate Doctor who is qualified to interpret lab work in the context of
    supplementation. This website is intended as information only. The editors of this site are not medically-
    trained. Please consult your licensed health care practitioner before implementing any health strategy.
    The information provided on this site is designed to support, not replace, the relationship that exists between
    a patient/site visitor and his/her existing physician. This site accepts no advertising.
    The contents of this site are copyrighted 2004-2010 by Breast Cancer Choices, Inc.
    Contact us with comments or for reprint permission at admin@breastcancerchoices.org

    Web page updated January 18,  2010.
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UPDATE:  April 2009

Iodine Investigation Project
Participants using the ATP
CoFactors  Formula report
they are absorbing iodine
faster.

Optimox now manufacturers
ATP Cofactors which seems to
be helping some people who
were not absorbing iodine
efficiently.


• Combination of Vitamins B2
and B3 in sustained-release
form
• Improves ATP (cell energy)
production
• Enhances transport and
liberation of iodine in target
tissues
• May help improve muscle
soreness associated with
fibromyalgia, when used with
Iodoral®

Don't like the taste
of salt water in the
bromide detox
cocktail?

Some participants
in the Iodine
Investigation
Project report they
can get similar
benefit  by putting
unrefined salt in
empty capsules and
drinking the
amount of water
suggested by
Dr. Shevin